FOXN1 antibody (N-Term)

Catalog No. ABIN7603147

The Rabbit Polyclonal anti-FOXN1 antibody has been validated for WB and FACS. It is suitable to detect FOXN1 in samples from Human, Rat and Mouse.

Quick Overview for FOXN1 antibody (N-Term) (ABIN7603147)

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXN1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-FOXN1 Antibody

Binding Specificity: N-Term

Purpose: Anti-FOXN1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FOXN1 Antibody Picoband® (ABIN7603147). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human FOXN1, which shares 85.7% amino acid (aa) sequence identity with mouse FOXN1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Adriani, M., Martinez-Mir, A., Fusco, F., Busiello, R., Frank, J., Telese, S., Matrecano, E., Ursini, M. V., Christiano, A. M., Pignata, C. Ancestral founder mutation of the nude (FOXN1) gene in congenital severe combined immunodeficiency associated with alopecia in southern Italy population. Ann. Hum. Genet. 68: 265-268, 2004. 2. Amorosi, S., D'Armiento, M., Calcagno, G., Russo, I., Adriani, M., Christiano, A. M., Weiner, L., Brissette, J. L., Pignata, C. FOXN1 homozygous mutation associated with anencephaly and severe neural tube defect in human athymic Nude/SCID fetus. Clin. Genet. 73: 380-384, 2008. 3. Auricchio, L., Adriani, M., Frank, J., Busiello, R., Christiano, A., Pignata, C. Nail dystrophy associated with a heterozygous mutation of the nude/SCID human FOXN1 (WHN) gene. Arch. Derm. 141: 647-648, 2005.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for FOXN1

Target: FOXN1 (Forkhead Box N1 (FOXN1))

Alternative Name: FOXN1

Background:

Synonyms: Vitamin D-binding protein, DBP, VDB, Gc-globulin, Group-specific component, Gc

Background: The FOXN1 gene encodes a transcription factor that regulates the development of epithelial cells in the thymus and skin. FOXN1 is expressed in thymic epithelial cell precursors which interact with T-cell progenitors for T-cell development in the thymus, and thus plays an essential role in thymic development beginning in the embryo. FOXN1 is also expressed in keratinocytes, hair follicles, epithelial cells in the nail matrix bed, and cells of the choroid plexus.

Molecular Weight: 69 kDa

Gene ID: 8456

UniProt: O15353